Abstract: Objective: It was elucidated the main components and mechanism of adjuvant prevention of type 2 Diabetes of citrus peel. Methods: The inhibitory activity of citrus peel of α-glycosidase was determined in vitro. It were used to predict the material basis and potential mechanism of tangerine peel in the treatment of type 2 diabetes by network pharmacology, and verified the results by molecular docking. Results: The α-glucosidase was inhibited by several citrus peel and showed a dose-effect relationship in the linear range. It was predicted that the active ingredients naringin, hesperin and lauric acid might inhibit hyperglycemia through oxidative stress by network pharmacology and molecular docking. Naringin was the main component ,which citrus peel treatment of type Ⅱ diabetes was related to PI3K-Akt, Ras, HIF-1 signaling pathway in inflammation and vascular related VEGF signaling pathway. Hesperidin was the main component. Conclusion: Citrus peel had an inhibitory effect on α-glycosidase , which might play a role in the prevention of type 2 diabetes.