Abstract: To understand whether there is a drug residue in the rose flower cake, and whether there is a risk of chronic dietary intake. In this paper, the residues of four avermectins in rose flower cake were detected, the residual levels of drug residues were analyzed, and the risk of chronic dietary intake was evaluated. The four drugs were avermectin, doramectin, acetylamineavermectin and ivermectin. A total of 43 rose flower cake samples were collected, and the optimized QuEChERS method was used to pre-treat the samples. The residue levels of the four compounds were determined by high performance liquid chromatography-tandem mass spectrometry, and their chronic dietary intake risk assessment and risk rank were performed. Results show that the four kinds of abamectin drugs line of correlation coefficient were greater than 0.99, the detection limit of the range of 0.1~0.7 µg/kg, recovery range of 94.97%~102.09%. Only avermectin was detected in the 4 target compounds, the detection rate is 79%, and residual range of 1.89~4.58 µg/kg. The food safety index analysis (IFS) of the four drugs was 1.3×10⁻³ for avermectin, 1.0×10⁻⁴ for doramectin, 1.7×10⁻⁶ for acetylavermectin, and 1.2×10⁻⁵ for ivermectin. Risk assessment on four kinds of target compounds, and to the risk of ordering, total four drugs are less than 50. This indicates that the residual level of avermectins in rose flower cakes is not high at present, and the risk is low. It is suggested that it should be included in the registration list of pesticides and the corresponding limit standards should be established.